:root{
  --blue:#1675a8;
  --cyan:#69c8df;
  --deep:#072f4a;
  --deep-2:#0a496d;
  --ink:#173447;
  --muted:#607584;
  --line:#d9e6ed;
  --pale:#f3f8fb;
  --white:#fff;
}

*{box-sizing:border-box}
html{scroll-behavior:smooth;scroll-padding-top:104px}
body{margin:0;color:var(--ink);background:#fff;font-family:system-ui,-apple-system,BlinkMacSystemFont,"Segoe UI",Arial,sans-serif;-webkit-font-smoothing:antialiased}
a{text-decoration:none;color:inherit}
img{max-width:100%}
.site-shell{width:min(1180px,calc(100% - 48px));margin:0 auto}

.site-header{position:sticky;top:0;z-index:100;height:88px;background:#fff;border-bottom:1px solid rgba(10,62,94,.12);box-shadow:0 4px 16px rgba(7,47,75,.055)}
.header-inner{height:100%;display:flex;align-items:center;justify-content:space-between;gap:32px}
.brand img{display:block;width:138px;height:auto}
.main-nav{display:flex;align-items:center;gap:29px}
.main-nav a{position:relative;padding:34px 0 31px;color:#2a4252;font-size:15px;font-weight:600;white-space:nowrap}
.main-nav a:after{content:"";position:absolute;left:0;right:0;bottom:21px;height:2px;background:var(--blue);transform:scaleX(0);transition:.2s}
.main-nav a:hover,.main-nav a.active{color:var(--blue)}
.main-nav a:hover:after,.main-nav a.active:after{transform:scaleX(1)}

.research-hero{position:relative;min-height:900px;padding:104px 0 0;color:#fff;background:linear-gradient(122deg,#052b45 0%,#084565 56%,#0c5d80 100%);overflow:hidden}
.hero-grid{position:absolute;inset:0;opacity:.16;background-image:linear-gradient(rgba(255,255,255,.12) 1px,transparent 1px),linear-gradient(90deg,rgba(255,255,255,.12) 1px,transparent 1px);background-size:62px 62px;mask-image:linear-gradient(90deg,transparent 0%,#000 44%,#000 100%)}
.hero-orbit{position:absolute;border:1px solid rgba(130,220,241,.2);border-radius:50%;pointer-events:none}
.hero-orbit-a{width:680px;height:680px;right:-260px;top:-325px;box-shadow:0 0 0 100px rgba(111,209,231,.035),0 0 0 205px rgba(111,209,231,.02)}
.hero-orbit-b{width:310px;height:310px;left:-145px;bottom:-140px;border-style:dashed}
.hero-layout{position:relative;z-index:2;display:grid;grid-template-columns:1.08fr .92fr;align-items:center;gap:58px}
.eyebrow{margin:0 0 18px;color:#9ddcec;font-size:14px;font-weight:700;letter-spacing:.14em}
.hero-copy h1{margin:0;color:#fff;font-size:clamp(47px,4.4vw,62px);line-height:1.16;letter-spacing:-.04em}
.hero-copy h1 span{display:inline-block;margin-top:8px;font-size:.82em;color:#c9f3ff}
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.hero-note{max-width:690px;margin:16px 0 0;padding-left:19px;border-left:2px solid var(--cyan);color:rgba(255,255,255,.7);font-size:14px;line-height:1.85}
.hero-actions,.cta-actions{display:flex;gap:14px;margin-top:31px}
.btn{display:inline-flex;min-height:49px;padding:0 25px;align-items:center;justify-content:center;border:1px solid transparent;border-radius:3px;font-size:15px;font-weight:700;transition:.2s}
.btn-white{background:#fff;color:var(--deep)}
.btn-white:hover{background:#def3f9}
.btn-outline{border-color:rgba(255,255,255,.68);color:#fff}
.btn-outline:hover{background:rgba(255,255,255,.1)}

.evidence-visual{position:relative;height:520px}
.evidence-visual>svg{position:absolute;inset:10px;width:calc(100% - 20px);height:calc(100% - 20px)}
.ev-ring,.ev-path{fill:none;stroke:rgba(151,224,241,.22);stroke-width:1.2}
.ev-ring-inner{stroke:rgba(151,224,241,.33);stroke-width:1.6}
.ev-path{stroke-width:1.4}.ev-dash{stroke-dasharray:6 8}
.ev-node{fill:#7ed4e8;filter:drop-shadow(0 0 9px rgba(126,212,232,.75))}
.evidence-core{position:absolute;left:50%;top:50%;width:178px;height:178px;display:flex;align-items:center;justify-content:center;flex-direction:column;border:1px solid rgba(164,230,244,.38);border-radius:50%;background:rgba(9,64,91,.65);box-shadow:0 0 0 18px rgba(111,209,231,.035),0 18px 48px rgba(0,22,37,.3);transform:translate(-50%,-50%);backdrop-filter:blur(8px)}
.evidence-core small{color:#8fd7e9;font-size:10px;font-weight:700;letter-spacing:.18em}
.evidence-core strong{margin-top:8px;color:#fff;font-size:27px;font-weight:600}
.evidence-core span{margin-top:7px;color:rgba(255,255,255,.58);font-size:11px}
.evidence-node{position:absolute;width:166px;min-height:76px;padding:14px 16px;display:flex;align-items:center;justify-content:center;flex-direction:column;text-align:center;border:1px solid rgba(255,255,255,.16);background:rgba(255,255,255,.075);box-shadow:0 10px 26px rgba(1,26,43,.14);backdrop-filter:blur(8px)}
.evidence-node strong,.evidence-node small{display:block}.evidence-node strong{color:#fff;font-size:16px}.evidence-node small{margin-top:5px;color:rgba(255,255,255,.58);font-size:11px}
.node-pk{left:50%;top:-18px;transform:translateX(-50%)}.node-effect{right:-38px;top:50%;transform:translateY(-50%)}.node-safety{left:50%;bottom:-18px;transform:translateX(-50%)}.node-use{left:-38px;top:50%;transform:translateY(-50%)}
.hero-stats{position:relative;z-index:3;display:grid;grid-template-columns:repeat(4,1fr);margin-top:58px;border-top:1px solid rgba(255,255,255,.17);border-bottom:1px solid rgba(255,255,255,.17)}
.hero-stats article{min-height:150px;padding:28px 27px;border-right:1px solid rgba(255,255,255,.15)}.hero-stats article:first-child{border-left:1px solid rgba(255,255,255,.15)}
.hero-stats strong{color:#fff;font-size:35px;font-weight:600;letter-spacing:-.04em}.hero-stats span{margin-left:6px;color:#9eddeb;font-size:13px;font-weight:700}.hero-stats p{margin:9px 0 0;color:rgba(255,255,255,.66);font-size:13px;line-height:1.6}

.section{position:relative;padding:108px 0;overflow:hidden}
.section-head{position:relative;z-index:2;max-width:820px;margin:0 0 53px}
.section-index{margin:0 0 16px;color:#6c91a5;font-size:13px;font-weight:700;letter-spacing:.1em}.section-index span{display:inline-flex;width:34px;height:34px;margin-right:11px;align-items:center;justify-content:center;border:1px solid #a9cbd9;border-radius:50%;color:var(--blue);letter-spacing:0}
.section-head h2{margin:0;color:var(--deep);font-size:clamp(38px,4vw,52px);font-weight:600;line-height:1.25;letter-spacing:-.035em}
.section-head>p:last-child{max-width:780px;margin:23px 0 0;color:var(--muted);font-size:17px;line-height:1.9}
.compact-head{max-width:900px}

.clinical-base{background:#fff}
.base-line-art{position:absolute;right:-80px;top:38px;width:520px;height:420px;opacity:.52}
.base-line-art:before,.base-line-art:after{content:"";position:absolute;border:1px solid #dcecf2;border-radius:50%}.base-line-art:before{width:360px;height:360px;right:0;top:0}.base-line-art:after{width:240px;height:240px;right:60px;top:60px}
.base-line-art i{position:absolute;right:175px;width:180px;height:1px;background:#cfe5ed;transform-origin:right}.base-line-art i:nth-child(1){top:110px;transform:rotate(-28deg)}.base-line-art i:nth-child(2){top:205px}.base-line-art i:nth-child(3){top:295px;transform:rotate(28deg)}.base-line-art span{position:absolute;right:170px;top:199px;width:12px;height:12px;border:3px solid var(--cyan);border-radius:50%}
.application-grid{position:relative;z-index:2;display:grid;grid-template-columns:repeat(3,1fr);gap:18px}
.application-grid article{position:relative;min-height:250px;padding:30px 30px 27px;border:1px solid var(--line);background:linear-gradient(145deg,#fff,#f8fbfc);box-shadow:0 16px 42px rgba(6,54,83,.055);overflow:hidden}
.application-grid article:after{content:"";position:absolute;width:170px;height:170px;right:-76px;bottom:-84px;border:1px solid #d7eaf1;border-radius:50%;box-shadow:0 0 0 28px rgba(105,200,223,.045)}
.application-no{position:absolute;right:22px;top:22px;color:#9bb5c2;font-size:12px;font-weight:700}
.application-symbol{width:72px;height:72px;display:flex;align-items:center;justify-content:center;border:1px solid #b7d8e4;border-radius:50%;color:var(--blue);background:#eff8fb;font-size:17px;font-weight:700;letter-spacing:.05em}
.application-grid h3{margin:28px 0 0;color:var(--deep);font-size:26px;font-weight:600}.application-grid p{margin:9px 0 0;color:#7794a3;font-size:11px;font-weight:700;letter-spacing:.14em}
.application-summary{position:relative;z-index:2;display:flex;align-items:center;justify-content:center;gap:23px;margin-top:24px;padding:20px;border:1px solid #d6e6ed;background:#f5fafc;color:#3c6479;font-size:15px;font-weight:600}.application-summary i{width:5px;height:5px;border-radius:50%;background:var(--cyan)}

.evidence-framework{color:#fff;background:linear-gradient(125deg,#062e49 0%,#084866 58%,#0b5c7e 100%)}
.framework-grid{position:absolute;inset:0;opacity:.12;background-image:linear-gradient(rgba(255,255,255,.15) 1px,transparent 1px),linear-gradient(90deg,rgba(255,255,255,.15) 1px,transparent 1px);background-size:58px 58px;mask-image:linear-gradient(90deg,#000,transparent 75%)}
.framework-orbit{position:absolute;right:-250px;bottom:-320px;width:760px;height:760px;border:1px solid rgba(123,216,237,.14);border-radius:50%;box-shadow:0 0 0 100px rgba(123,216,237,.025),0 0 0 200px rgba(123,216,237,.015)}
.light-head .section-index{color:#91c9d8}.light-head .section-index span{border-color:rgba(151,220,237,.55);color:#b9edf7}.light-head h2{color:#fff}.light-head>p:last-child{color:rgba(255,255,255,.7)}
.evidence-grid{position:relative;z-index:2;display:grid;grid-template-columns:repeat(4,1fr);gap:1px;background:rgba(255,255,255,.13);border:1px solid rgba(255,255,255,.14)}
.evidence-grid article{position:relative;min-height:338px;padding:30px 28px;background:rgba(6,51,76,.72)}
.evidence-grid article>span{position:absolute;right:23px;top:21px;color:rgba(158,220,236,.45);font-size:12px;font-weight:700}
.evidence-icon{width:76px;height:76px;position:relative;display:flex;align-items:center;justify-content:center;border:1px solid rgba(143,216,233,.34);border-radius:50%;background:rgba(255,255,255,.04)}
.evidence-icon svg{width:48px}.evidence-icon path,.evidence-icon line{fill:none;stroke:#8ed9e9;stroke-width:2}
.evidence-grid h3{margin:25px 0 13px;color:#fff;font-size:21px}.evidence-grid p{margin:0;color:rgba(255,255,255,.68);font-size:14px;line-height:1.85}
.icon-effect i{position:absolute;width:36px;height:1px;background:#8ed9e9;transform-origin:left}.icon-effect i:nth-child(1){transform:rotate(-35deg);left:20px;top:45px}.icon-effect i:nth-child(2){transform:rotate(23deg);left:31px;top:25px}.icon-effect i:nth-child(3){width:10px;height:10px;right:16px;top:30px;border:2px solid #8ed9e9;border-radius:50%;background:transparent}.icon-effect strong{position:absolute;left:17px;bottom:13px;color:#8ed9e9;font-size:15px}
.icon-user b{position:absolute;width:17px;height:17px;border:2px solid #8ed9e9;border-radius:50%;top:17px}.icon-user b:after{content:"";position:absolute;left:50%;top:20px;width:28px;height:19px;border:2px solid #8ed9e9;border-bottom:0;border-radius:17px 17px 0 0;transform:translateX(-50%)}.icon-user b:nth-child(1){left:12px;transform:scale(.72)}.icon-user b:nth-child(2){left:28px}.icon-user b:nth-child(3){right:12px;transform:scale(.72)}
.research-network{position:relative;z-index:2;display:grid;grid-template-columns:1fr 200px 200px;align-items:stretch;margin-top:25px;border:1px solid rgba(255,255,255,.15);background:rgba(255,255,255,.07)}
.research-network>div{padding:28px 33px}.network-label{margin:0 0 8px;color:#8fd8e9;font-size:11px;font-weight:700;letter-spacing:.13em}.research-network h3{margin:0;color:#fff;font-size:22px}.research-network>div>p:last-child{margin:11px 0 0;color:rgba(255,255,255,.65);font-size:14px;line-height:1.75}
.research-network article{display:flex;align-items:center;justify-content:center;gap:13px;border-left:1px solid rgba(255,255,255,.14)}.research-network strong{color:#fff;font-size:38px;font-weight:600}.research-network span{color:rgba(255,255,255,.63);font-size:12px;line-height:1.55}

.insulin-case{background:#fff}
.case-orbit{position:absolute;left:-370px;top:90px;width:620px;height:620px;border:1px solid #e0eef3;border-radius:50%;box-shadow:0 0 0 82px rgba(105,200,223,.025),0 0 0 165px rgba(105,200,223,.016)}
.case-intro{position:relative;z-index:2;display:grid;grid-template-columns:minmax(0,1.18fr) minmax(430px,.82fr);gap:54px;align-items:stretch;margin-bottom:56px}
.case-head{max-width:none;margin-bottom:0}.case-head>p:last-child{max-width:690px}
.case-comparison{position:relative;align-self:stretch;min-height:286px;padding:24px 0 17px;border-top:1px solid #c9dfe8;border-bottom:1px solid #c9dfe8;background:linear-gradient(112deg,rgba(242,249,251,.15),rgba(231,244,248,.72));overflow:hidden}
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.case-compare-top,.case-compare-grid,.case-compare-note{position:relative;z-index:2}
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.case-compare-grid article{min-width:0;padding:16px 11px 14px;border-left:1px solid rgba(152,194,209,.42)}.case-compare-grid article:first-child{border-left:0}.case-compare-grid svg{display:block;width:100%;height:70px;overflow:visible}
.case-compare-grid h3{min-height:38px;margin:8px 0 2px;color:#204f66;font-size:12px;font-weight:700;line-height:1.5}.case-compare-grid p{margin:0;color:#829ca8;font-size:9px;line-height:1.45}
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.case-mark{position:relative;min-height:560px;padding:48px 38px;display:flex;flex-direction:column;justify-content:flex-end;color:#fff;background:linear-gradient(150deg,#07334f,#0b6788);overflow:hidden}
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.case-mark:after{content:"";position:absolute;inset:0;opacity:.13;background-image:linear-gradient(rgba(255,255,255,.15) 1px,transparent 1px),linear-gradient(90deg,rgba(255,255,255,.15) 1px,transparent 1px);background-size:44px 44px;mask-image:linear-gradient(145deg,#000,transparent 72%)}
.case-mark small,.case-mark strong,.case-mark span,.case-mark i{position:relative;z-index:2}.case-mark small{color:#9eddea;font-size:11px;font-weight:700;letter-spacing:.15em}.case-mark strong{margin-top:11px;font-size:51px;font-weight:500;letter-spacing:.02em}.case-mark span{margin-top:13px;color:rgba(255,255,255,.72);font-size:18px;line-height:1.6}.case-mark i{width:58px;height:3px;margin-top:27px;background:var(--cyan)}
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.case-steps article{position:relative;min-height:186px;display:grid;grid-template-columns:49px 1fr;gap:14px;padding:28px 25px;border-right:1px solid var(--line);border-bottom:1px solid var(--line);background:#fff}
.case-steps article:before{content:"";position:absolute;left:47px;top:67px;bottom:-120px;width:1px;background:#d7e7ed}.case-steps article:nth-last-child(-n+2):before{display:none}
.case-steps>article>span{width:43px;height:43px;display:flex;align-items:center;justify-content:center;border:1px solid #a9cedb;border-radius:50%;color:var(--blue);background:#f3fafc;font-size:12px;font-weight:700}
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.frontier{background:var(--pale)}
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.frontier-grid article{position:relative;min-height:460px;padding:31px 34px 32px;border:1px solid #d5e5ec;background:rgba(255,255,255,.92);box-shadow:0 18px 50px rgba(6,54,83,.055);overflow:hidden}
.frontier-grid article:after{content:"";position:absolute;right:-120px;bottom:-130px;width:260px;height:260px;border:1px solid #d8eaf0;border-radius:50%;box-shadow:0 0 0 40px rgba(105,200,223,.035)}
.frontier-top{display:flex;align-items:center;justify-content:space-between}.frontier-top span{display:flex;width:34px;height:34px;align-items:center;justify-content:center;border:1px solid #a9ccda;border-radius:50%;color:var(--blue);font-size:11px;font-weight:700}.frontier-top strong{color:#89a8b6;font-size:10px;letter-spacing:.16em}
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.frontier-grid h3{margin:0 0 14px;color:var(--deep);font-size:24px}.frontier-grid>article>p{margin:0;color:var(--muted);font-size:15px;line-height:1.85}.frontier-grid>article>small{display:block;margin-top:20px;padding-top:17px;border-top:1px solid #e0ebf0;color:#49758a;font-size:13px;font-weight:600;line-height:1.7}

.publications{background:#fff}
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.publication-grid{position:relative;z-index:2;display:grid;grid-template-columns:repeat(6,1fr);gap:18px}
.publication-grid article{position:relative;min-height:318px;padding:27px 25px;border:1px solid var(--line);background:linear-gradient(150deg,#fff,#f7fbfc);overflow:hidden}.publication-grid article:nth-child(-n+3){grid-column:span 2}.publication-grid article:nth-child(n+4){grid-column:span 3}
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.publication-grid article>span{display:flex;width:32px;height:32px;align-items:center;justify-content:center;border-radius:50%;background:#eaf5f8;color:var(--blue);font-size:11px;font-weight:700}
.publication-type{margin:24px 0 8px;color:#7e9dab;font-size:10px;font-weight:700;letter-spacing:.13em}.publication-grid h3{margin:0;color:var(--deep);font-size:21px}.publication-grid article>p:not(.publication-type){margin:13px 0 0;color:var(--muted);font-size:14px;line-height:1.75}
.publication-link{position:absolute;left:25px;bottom:24px;display:inline-flex;align-items:center;gap:8px;color:#1a719b;font-size:13px;font-weight:700}.publication-link b{font-size:16px;transition:transform .2s}.publication-link:hover b{transform:translateX(4px)}
.publication-actions{position:relative;z-index:2;display:flex;justify-content:flex-end;gap:12px;margin-top:25px}.publication-actions a{display:inline-flex;min-height:48px;padding:0 22px;align-items:center;justify-content:center;border:1px solid #b8d2dd;color:#245f7b;background:#fff;font-size:14px;font-weight:700}.publication-actions a:last-child{border-color:var(--blue);color:#fff;background:var(--blue)}

.research-cta{position:relative;padding:78px 0;color:#fff;background:linear-gradient(115deg,#07314e,#0b6488);overflow:hidden}.cta-pattern{position:absolute;inset:0;opacity:.15;background-image:linear-gradient(rgba(255,255,255,.14) 1px,transparent 1px),linear-gradient(90deg,rgba(255,255,255,.14) 1px,transparent 1px);background-size:58px 58px;mask-image:linear-gradient(90deg,transparent,#000)}
.cta-layout{position:relative;z-index:2;display:grid;grid-template-columns:1fr auto;align-items:center;gap:60px}.cta-layout h2{margin:0;color:#fff;font-size:clamp(35px,3.7vw,48px);line-height:1.25}.cta-layout>div>p:last-child{max-width:750px;margin:18px 0 0;color:rgba(255,255,255,.72);font-size:16px;line-height:1.85}.cta-actions{margin-top:0;white-space:nowrap}

.site-footer{padding:67px 0 24px;background:#06283d;color:#fff}.footer-main{display:grid;grid-template-columns:1fr auto;gap:70px;padding-bottom:44px}.footer-brand img{width:150px;filter:brightness(0) invert(1);margin-bottom:20px}.footer-brand h2{margin:0 0 9px;color:#fff;font-size:20px}.footer-brand p{margin:0;color:rgba(255,255,255,.6);font-size:14px}.footer-nav{display:grid;grid-template-columns:repeat(3,auto);gap:17px 32px;align-content:start}.footer-nav a{color:rgba(255,255,255,.72);font-size:14px}.footer-nav a:hover{color:#fff}.footer-bottom{display:flex;justify-content:space-between;padding-top:18px;border-top:1px solid rgba(255,255,255,.13);color:rgba(255,255,255,.45);font-size:12px}.footer-bottom a{color:inherit}

@media(max-width:1100px){
  .main-nav{gap:17px}.main-nav a{font-size:13px}
  .hero-layout{grid-template-columns:minmax(0,1fr);gap:28px}.research-hero{padding-top:82px}.evidence-visual{width:600px;max-width:100%;margin:0 auto}.hero-stats{margin-top:35px}
  .evidence-grid{grid-template-columns:repeat(2,1fr)}.evidence-grid article{min-height:290px}.research-network{grid-template-columns:1fr 180px 180px}
  .case-intro{grid-template-columns:1fr;gap:30px}.case-head>p:last-child{max-width:820px}.case-comparison{width:100%;min-height:270px}.case-compare-grid h3{min-height:auto;font-size:14px}.case-compare-grid p{font-size:10px}.case-layout{grid-template-columns:.62fr 1.38fr;gap:35px}.case-mark{padding:38px 28px}.case-steps article{padding:24px 20px}
  .cta-layout{grid-template-columns:1fr}.cta-actions{margin-top:0}
}

@media(max-width:820px){
  html{scroll-padding-top:132px}.site-shell{width:min(100% - 32px,680px)}
  .site-header{height:auto}.header-inner{display:block;padding:15px 0}.brand img{width:118px}.main-nav{margin-top:12px;padding-top:12px;border-top:1px solid var(--line);gap:10px 20px;overflow:auto}.main-nav a{padding:5px 0 8px}.main-nav a:after{bottom:0}
  .research-hero{min-height:auto;padding-top:70px}.hero-copy h1{font-size:43px}.hero-lead{font-size:16px}.evidence-visual{height:470px}.hero-stats{grid-template-columns:repeat(2,1fr)}.hero-stats article:nth-child(3){border-left:1px solid rgba(255,255,255,.15);border-top:1px solid rgba(255,255,255,.15)}.hero-stats article:nth-child(4){border-top:1px solid rgba(255,255,255,.15)}
  .section{padding:82px 0}.section-head{margin-bottom:39px}.section-head h2{font-size:36px}.section-head>p:last-child{font-size:16px}
  .application-grid{grid-template-columns:1fr}.application-grid article{min-height:210px}.application-summary{flex-wrap:wrap}
  .evidence-grid{grid-template-columns:1fr}.evidence-grid article{min-height:auto}.research-network{grid-template-columns:1fr 1fr}.research-network>div{grid-column:1/-1}.research-network article{min-height:120px;border-top:1px solid rgba(255,255,255,.14)}
  .case-intro{margin-bottom:40px}.case-comparison{min-height:0}.case-layout{grid-template-columns:1fr}.case-mark{min-height:360px}.case-steps{grid-template-columns:1fr}.case-steps article:before{bottom:-120px}.case-steps article:nth-last-child(2):before{display:block}
  .frontier-grid{grid-template-columns:1fr}.frontier-grid article{min-height:auto}
  .publication-grid{grid-template-columns:1fr}.publication-grid article,.publication-grid article:nth-child(-n+3),.publication-grid article:nth-child(n+4){grid-column:auto;min-height:270px}.publication-actions{justify-content:flex-start;flex-wrap:wrap}
  .footer-main{display:block}.footer-nav{margin-top:30px;grid-template-columns:repeat(2,1fr)}
}

@media(max-width:560px){
  .site-shell{width:calc(100% - 28px)}.main-nav{gap:10px 18px}
  .research-hero{padding-top:54px}.hero-copy h1{font-size:34px}.hero-copy h1 span{font-size:.88em}.hero-actions,.cta-actions{align-items:stretch;flex-direction:column}.btn{width:100%}
  .evidence-visual{height:400px;margin-top:18px}.evidence-visual>svg{inset:28px;width:calc(100% - 56px);height:calc(100% - 56px)}.evidence-core{width:136px;height:136px}.evidence-core strong{font-size:21px}.evidence-node{width:132px;min-height:66px;padding:11px 12px}.evidence-node strong{font-size:13px}.evidence-node small{font-size:9px}.node-pk{top:-2px}.node-safety{bottom:-2px}.node-effect{right:-4px}.node-use{left:-4px}
  .hero-stats{margin-top:25px}.hero-stats article{min-height:132px;padding:23px 19px}.hero-stats strong{font-size:29px}.hero-stats p{font-size:12px}
  .section{padding:68px 0}.section-head h2{font-size:29px}.section-head>p:last-child{font-size:15px}.section-index{font-size:12px}.section-index span{width:31px;height:31px}
  .application-grid article{padding:25px;min-height:190px}.application-grid h3{font-size:23px}.application-summary{gap:12px 16px;font-size:13px}.application-summary i{display:none}
  .evidence-grid article{padding:26px 24px}.research-network{grid-template-columns:1fr}.research-network article{border-left:0}.research-network article:last-child{border-top:0}.research-network>div{padding:25px 24px}.research-network h3{font-size:20px}
  .case-compare-top{align-items:flex-start;flex-direction:column;gap:8px;padding:0 14px 14px}.case-compare-top>span,.case-legend{font-size:10px}.case-compare-grid{grid-template-columns:repeat(2,1fr)}.case-compare-grid article:nth-child(3){border-left:0}.case-compare-grid article:nth-child(n+3){border-top:1px solid rgba(152,194,209,.42)}.case-compare-grid h3{font-size:13px}.case-compare-grid p{font-size:11px}.case-compare-note{margin:10px 14px 0;font-size:10px}.case-mark{min-height:300px}.case-mark strong{font-size:43px}.case-steps article{grid-template-columns:43px 1fr;padding:23px 18px}.case-steps h3{font-size:17px}.case-conclusion{font-size:14px}
  .frontier-grid article{padding:27px 24px}.frontier-figure b{font-size:42px}.frontier-grid h3{font-size:22px}.frontier-grid>article>p{font-size:14px}
  .publication-grid article{padding:25px 22px}.publication-link{left:22px}.publication-actions a{width:100%}.research-cta{padding:65px 0}.cta-layout h2{font-size:30px}
  .footer-bottom{flex-direction:column;gap:8px}
}

/* 14英寸笔记本阅读校准：临床结论与图表说明不再使用过小字号 */
@media(min-width:821px){
  .section-index{font-size:14px}
  .evidence-core small{font-size:11px}.evidence-core span{font-size:12px}.evidence-node strong{font-size:17px}.evidence-node small{font-size:12px}
  .hero-stats p{font-size:14px}.application-grid p{font-size:12px}
  .evidence-grid p{font-size:15px}.network-label{font-size:12px;white-space:nowrap}.research-network>div>p:last-child{font-size:15px}.research-network span{font-size:13px}
  .case-compare-top>span,.case-legend{font-size:11px}.case-compare-grid h3{min-height:42px;font-size:14px}.case-compare-grid p{font-size:12px}.case-compare-note{font-size:11px}
  .case-steps p{font-size:15px}.frontier-top strong{font-size:11px}.frontier-figure em{font-size:13px}.frontier-grid>article>small{font-size:14px}
  .publication-type{font-size:11px}.publication-grid article>p:not(.publication-type){font-size:15px}.publication-link{font-size:14px}
}

/* Research sources follow the page's questions; details keep the main section compact. */
.publication-grid article:nth-child(n+4){grid-column:span 2}.research-directory{position:relative;z-index:2;margin-top:48px}.research-directory>h3{color:var(--deep);font-size:25px}.research-directory-note{max-width:880px;color:var(--muted);line-height:1.8}.research-group{scroll-margin-top:100px;border-bottom:1px solid #c9dce5;background:rgba(255,255,255,.85)}.research-group summary{cursor:pointer;padding:23px 24px;color:var(--deep);font-weight:700;font-size:18px}.research-group summary span{float:right;font-size:13px;color:#547b90;font-weight:400}.research-entries{padding:0 24px 12px}.research-entry{padding:22px 0;border-top:1px solid #e0ebef}.research-meta{font-size:12px;color:#658093}.research-entry h4{margin:8px 0;font-size:17px;line-height:1.6;color:var(--deep);overflow-wrap:anywhere}.research-entry p{font-size:14px;line-height:1.8;color:var(--muted)}.research-links{display:flex;flex-wrap:wrap;gap:14px}.research-links a{color:#136b99;font-size:14px;font-weight:600;border-bottom:1px solid #b7d2df}.research-links a:focus-visible,.research-group summary:focus-visible{outline:2px solid #136b99;outline-offset:4px}
@media(max-width:800px){.publication-grid article:nth-child(n+4){grid-column:auto}.research-group summary{padding:20px 16px;font-size:16px}.research-group summary span{float:none;display:block;margin-top:8px}.research-entries{padding:0 16px 12px}}

/* Prevent single-column hero graphics from expanding the mobile text column */
.hero-layout>div{min-width:0}

/* Keep corner arc decorations behind card content. */
.application-grid article{isolation:isolate}
.application-grid article:after{z-index:-1;pointer-events:none}
.frontier-grid article{isolation:isolate}
.frontier-grid article:after{z-index:-1;pointer-events:none}

.publication-grid article{isolation:isolate}.publication-grid article:after{z-index:-1;pointer-events:none}

.application-grid article:after{transform:translateY(30%)}
.frontier-grid article:after{transform:translateY(30%)}